Full-timeHealthcare & care· Posted 1 Oct

Associate Scientist/Scientist, mRNA Process Development

A*STARFrom company site

Salary

Not stated by the company

When

Full-time hours

Where

Singapore

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Start: Not stated
Work mode: On-site
Experience: Experienced

About the role

NATi, a national RNA therapeutics platform hosted by A*STAR, is hiring a scientist to develop mRNA vaccines and immunotherapies across several therapeutic programmes. You will join a biotech-style translational team working from discovery and pre-clinical stages through to IND-enabling work. This suits an experienced laboratory scientist with a strong track record in academic or biotech settings who enjoys a fast-moving, multidisciplinary environment.

What you'll do

Develop processes for making bacterial plasmid DNA, cell-free DNA and in-vitro transcribed mRNA across RNA modalities such as circRNA, saRNA and linear mRNA
Develop purification methods including chromatography and tangential flow filtration for plasmid DNA, cell-free DNA and mRNA

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Develop DNA and mRNA characterisation tools such as capillary gel electrophoresis, HPLC, ELISA, cell-based protein expression, UV spectroscopy and fluorescence assays

Develop and maintain SOPs and batch records for reproducibility, compliance and IND submission readiness

Keep accurate records in LIMS/ELN systems to support data integrity and reproducibility

Prepare technical reports, presentations and documentation for internal decisions and external regulatory submissions

Support tech transfer to external CDMOs, including reports, training and troubleshooting

Support regulatory submissions by producing reports and contributing to CMC documentation

Good to know

Location: Singapore
Industry experience is preferred but not required

Requirements

BS or MS in Biochemistry, Molecular Biology, Biochemical Engineering, Pharmaceutical Sciences or a related field
At least 4 years of relevant experience with an MS degree, or at least 7 years with a BS degree, in RNA biochemistry or pharmaceutical sciences
Skilled in designing and running ex-vivo cell-based assays
Hands-on experience with ELISA, Western Blot, SDS-PAGE and standard molecular biology and RNA biochemistry tools such as primer design, cloning, RT-PCR, PCR, and DNA/RNA extraction and purification
Able to use SnapGene, GraphPad Prism and Excel
Strong problem-solving and decision-making skills, able to troubleshoot experimental processes and provide analysis

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Associate Scientist/Scientist, mRNA Process Development

About the role

What you'll do

Good to know

Requirements

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