Full-timeHealthcare & care· Posted 2 Oct

Research Fellow (CSCB/OST)

Duke-NUS Medical SchoolFrom company site

Salary

Not stated by the company

When

Full-time hours

Where

Outram

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Start: Not stated
Work mode: On-site
Experience: Some experience

About the role

A translational research lab focused on immune-based therapies for blood cancers and Asian-specific solid tumours is looking for a post-doctoral Research Fellow. The role centres on natural killer (NK) cell research, combining single-cell profiling and AI/ML-guided discovery with laboratory validation. It suits a recently qualified PhD holder with strong hands-on NK cell and animal model experience who can drive an independent research programme.

What you'll do

Independently design and run the NK cell research programme, covering in vitro expansion, engineering and functional characterisation against blood cancers and solid tumours.
Set up, optimise and operate NK cell in vitro expansion platforms such as feeder cell-based, cytokine-driven and iPSC-derived systems.

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Develop and carry out NK cell functional assays, including cytotoxicity assays (flow-based, luciferase, real-time impedance), degranulation (CD107a), cytokine production, ADCC and multi-colour flow cytometry immunophenotyping.

Design and conduct in vivo studies in mouse tumour models (xenograft and syngeneic leukaemia and solid tumour models) to assess NK cell persistence, trafficking and anti-tumour efficacy.

Maintain rigorous, reproducible experimental outcomes with careful record-keeping and data analysis.

Translate findings into publications, presentations and new research directions.

Develop plans for independent research with field-level impact and help attract research funding.

Support external grant and protocol development, study design and research activity management, including regulatory and IACUC documentation for animal work.

Guide and mentor undergraduate students and research assistants, contributing to team development and scientific direction.

Perform other related duties incidental to the work described.

Good to know

Location: Outram Campus, Singapore.
Organisation: Duke-NUS Medical School, Office of Research.
Employee referral eligible: No.
Only shortlisted candidates will be notified.

Requirements

PhD in Immunology, Cancer Biology, Cell Therapy or a related scientific discipline, or an equivalent postgraduate degree with a strong research track record
Demonstrated expertise in NK cell biology with hands-on experience in NK cell in vitro expansion platforms and functional assays
Strong laboratory experimental experience and ability to work independently and rigorously
Hands-on experience with mouse tumour models, including study design, dosing and endpoint analyses
Familiarity with iPSC-based platforms is an advantage
Proficiency in multi-colour flow cytometry and cell-based cytotoxicity/immune-function assays

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Duke-NUS Medical School

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Research Fellow (CSCB/OST)

About the role

What you'll do

Good to know

Requirements

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